Laurence Lee

March 20, 2022 in Supplements

The brain is undeniably the most intriguing component of the human body. It is made up of billions of neurons and unique processes that each play a distinct role in everything we do. While there is still a great deal that researchers are yet to find out about this complex organ, one thing is certain, we need to enhance and maintain cognitive function to the best of our abilities. 

This can be done with nootropic agents. Nootropic agents, also known as cognitive enhancers, are supplemental treatments used to improve memory and elevate mental alertness and concentration. It also increases energy levels and wakefulness, making it an excellent choice for healthy individuals looking to increase/maintain their mental abilities or those with mental ailments. 

Besides having a profound effect on users' mental state, these agents also positively affect physical capabilities, allowing users to be more productive and efficient. Due to the comprehensive list of benefits accompanying nootropic use, several companies have created supplements containing these agents, causing a highly saturated nootropic industry.

This makes it difficult to choose the best option. Below we compare two of the best nootropic agents on the market:

About NooCube

Wolfson Brands introduced this unique brain booster to the consumer market in 2016. Soon after its release, it became one of the leading names in the health supplement industry. Wolfson produces premium-quality dietary supplements that are CGMP certified, which means they are manufactured in FDA-approved research facilities. 

This potent nootropic agent was designed to enhance cognitive performance and brain functioning. It profoundly affects creativity, memory, recollection, mental focus, and speed. The supplement can be used by both males and females above 18 years old and does not carry any adverse effects which can harm the user's overall health.

Noocube contains an ideal blend of all-natural ingredients that have been clinically proven to increase mental energy, promote concentration levels and support overall brain health. The supplement uses a distinct formula that contains Alpha GPC which promotes neurotransmitter functionality which provides users with enhanced learning and problem-solving skills.

It produces potent effects that directly improve mental clarity and enhance cognitive responses. The perfect balance of ingredients also positively influences moods and emotions, which help users stay mentally grounded. In essence, it's an upgraded version of several nootropic supplements wrapped up in one convenient pill. 

Its potency comes with a low-risk profile as it does not contain caffeine or other stimulants. It is also gluten-free, Non-GMO, and effective enough to improve symptoms of neurodegenerative diseases like Alzheimer's disease, memory loss, and more.

About Alpha Brain

Alpha Brain is an all-inclusive brain booster distributed by Onnit, a world-renowned manufacturer of high-quality nootropics. Onnit was founded in 2010 with the aim of creating products that induced total human optimization. Today, there are over 250 products carrying the Onnit brand, making it a prominent figure in the health and wellness industry.

One of their best sellers is their flagship nootropic, Alpha Brain, which has dominated the market since its release in 2011. The clinically researched dietary supplement was made to provide users with daily cognitive support that optimizes brain functionality.

The product was made using a clinically tested, completely natural ingredient formula that can be safely used in conjunction with other supplements. This formula promotes alpha wave and neurotransmitter production, allowing it to work in rhythm with the brain's existing processing circuitry to facilitate memory, focus, and overall cognition.

The unique ingredients in the product also positively influence recent verbal memory and executive function. In addition, it improves cellular functioning and blood flow, which supports consistency and creativity. The supplement also promotes flow state, which helps users become more efficient and fully immersed in mental activities. 

The product has scientific evidence, celebrity endorsements, and user reviews that confirm the supplement's effectiveness and safety. Alpha Brain is also caffeine, dairy, gluten, and nut-free, with keto and paleo-friendly status, making it a great option for sensitive users or those with diet restrictions.

Key Features


- Strengthens the brain's ability to create neural connections.

- Reduces swelling/ inflammation or damage in the brain.

- Enhanced cognitive function, concentration, and focus

- Promotes blood flow to and from the brain.

- Facilitates learning and memory functions.

- Mental energy and multitasking support.

Alpha Brain

- Improves memory and overall cognitive functions.

- Promotes Alpha brain waves—'flow state' focus.

- Boost concentrations and enhances focus.

- Supports brain and mental health.

- Speeds up response/reactions times.

- Reduces anxiety and stress.


NooCube and Alpha Brain contain natural premium ingredients that were scientifically proven to be effective in their purpose. Their unique formulas have the innate ability to influence, improve and maintain optimal mental processes. 

Although these supplements hail from completely different companies and use different mechanisms of action to execute their function, they have some ingredients in common. 

Common ingredients seen in both the NooCube and AlphaBrain formula include:



Alpha Brain

Alpha GPC


Dose Unknown

Bacopa Monnieri







Dose Unknown



Dose Unknown

Oat Straw


Dose Unknown



Dose Unknown



The higher concentrated supplement is hard to identify considering that most of the ingredient volumes are unknown in Alpha Brain. This does not mean that either supplement is less or more effective—when it comes to cognitive enhancers, many experts believe that a choice should be made based on user preference rather than the ingredient volume.

Unique ingredients in Noocube

NooCube's formula contains 13 clinically tested ingredients that are highly effective in enhancing cognitive abilities. Some of the unique ingredients in the formula are listed below:

  • Vitamin B1: Vitamin B1, also known as the "morale vitamin," positively affects attitude and brain function, which helps improve memory and concentration.
  • Vitamin B7: This vitamin promotes the appropriate function of the nervous system, which is also essential for liver metabolism.
  • Vitamin B12: This vitamin plays a vital role in the function and development of the brain, blood/ nerve cells, and the myelin sheaths that protect nerves. It improves memory, concentration, moods, and mental energy.
  • Resveratrol: The ingredient improves learning, memory, moods, and cognitive reserves. It also promotes cerebral blood flow and cerebral vasodilator responsiveness.
  • Lutemax

Unique ingredients in Alpha Brain

Alpha Brain's 11 ingredient formula produces a host of benefits that positively affect both the body and mind. Below are the most unique components of the supplement:

  • Phosphatidylserine: Improves attention, language, thinking, and memory skills
  • Vitamin B6: This vitamin helps the body create neurotransmitters that send and receive messages from the brain. It also regulates mental energy use.
  • L-Leucine Branched-chain amino acid, L-Leucine, enters the brain from the blood more rapidly than any other amino acid. It facilitates the constant supply of glutamate, which supports concentration and protein synthesis.

Side Effects

NooCube and AlphaBrain have been at the forefront of the fight against sluggish brains for just over a decade now. Both supplements have an excellent safety and efficacy rate, contributing to their cascading benefits and millions of satisfied customers.

Although they are always portrayed in a positive light, consumers still worry about certain aspects of supplement use, one of them being the dreaded side effects. Upon investigation, we found no serious adversities linked to the use of either NooCube or Alpha Brain.

However, mild side effects may be present at the beginning of supplement use. These side effects include: 

  • Stomach aches.
  • Mood swings.
  • Headaches.

These effects often disappear on their own shortly after the body becomes familiar with the substance. Users are always encouraged to follow usage and dosage instructions to ensure they receive the intended results from supplement use.

Users who have allergies or sensitivity to any of the ingredients in these aids are advised to refrain from using them as it may induce adverse effects which can affect their cognitive and/or overall health. 

Prices and Offers

The price of NooCube and Alpha Brain can be found on the product's official site. Here users will find a plethora of information about these products and offers, which give users significant savings on multiple-unit orders.

Below we take a look at the price and offers unique to each of these brain enhancers

(60 capsules)
  • 1 Bottle: $59.99
  • 2 Bottles: $119.99 +1 bottle FREE + FREE gifts
  • 3 Bottle: $179.99 + 3 bottles FREE+ FREE gifts
Alpha Brain
(30 capsules and 90 capsules)
  • 1 bottle (30 capsules): $34.95
  • 1 bottles (90 capsules): $79.95
  • Multiple bottle orders are more affordable, with users saving more than 20% on a bottle
  • Subscription offers are also available

Both products come with FAST-FREE shipping on certain orders and a money-back guarantee which allows users to try these expert formulas risk-free.

Pros and Cons



  • Does not contain any stimulants, synthetic components, or genetically modified organisms.
  • Eliminates stress hormones improves moods, energy levels, and emotional capabilities.
  • Natural ingredients contents that are scientifically proven to be effective and safe.
  • Promotes better memory recall, critical thinking, focus, and concentration.


  • Initial use induces slight side effects
  • Noticeable effects are not seen immediately.

Alpha Brain


  • Supports all cognitive processes, including serotonin and dopamine balancing.
  • Effective formula that contains clinically researched all-natural ingredients.
  • User  friendly— gluten, nut,  stimulant-free, and keto/paleo-friendly.
  • Can be safely used in conjunction with other supplements.


  • Results only visible after 3-6 weeks of use.
  • Inconsistent use can affect positive results.

Final Verdict

Choosing the best option from these two supplements is difficult considering they both have a solid base, expertly designed formula, and natural ingredient contents. We kept our eyes peeled for any indicative red flags to make an informed decision.

The efficacy profile of both products is rather impressive however, Alpha Brain disappoints with their proprietary blend and lack of ingredient clarity. There is no clear idea of the volume of each ingredient which leaves a gap for possible shortfalls that could result in undesirable effects. 

NooCube creators, on the other hand, were transparent about their contents and formula, which we think contributes to the product's reliability status. The product contains clinically sound doses of effective ingredients, providing balanced effects and noticeable benefits.   

We think that the supplement's effect on mood, anxiety and stress levels is incomparable. NooCube also directly affects mental energy, concentration, and overall brain health, which in our books encapsulate what users should be looking for in a brain enhancer.

These beneficial results are unfortunately not immediately seen—consistent use produces the best results, which we think is a small price to pay for an overwhelming set of results. In essence, the excellent ingredient list, supportive studies, positive feedback, and actual results produced by NooCube make it the better choice. We can definitely say the product wins the battle on every front, including the price.

About the author 

Laurence Lee

Lee is a neuroscientist who has dedicated his career to understanding the inner workings of the brain. He has seen firsthand the power of these supplements in improving cognitive function and believes that more people should be aware of their benefits. In his articles, Lee shares his extensive knowledge on the subject and provides unbiased reviews of different products.

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