Laurence Lee

February 5, 2023 in Supplements

The brain is the central control room for everything our mind and body do. From our actions to reactions, the brain controls them all. Just like other organs, the brain needs support to function at its peak.

With their effective, non-invasive approach, nootropics agents are the best choice for cognitive improvement and maintenance. Besides improving mental processes, nootropics also provide an energy boost which positively influences how users carry out mental and physical tasks and activities. 

Let’s take a closer look at some of the best nootropic agents available in the market:

Best Nootropics for Energy



Best overall



Best for alertness and focus


Mind Lab Pro

Best for thinking efficiency 



Best for cognitive performance


Alpha Brain

Best for concentration and memory

1. Vyvamind

Vyvamind is a neurostimulator designed to enhance brain function and cognition in adults. With its high potency formula containing natural nootropics, the product claims to be a safe alternative to amphetamine-based supplements such as Adderall.

Vyvamind reduces brain fatigue/fog, negative moods, and distractions to help users reach optimal levels of focus.

It also positively influences communication, learning, understanding, and memory storage by supporting healthy brain chemical flow. The supplement uses Caffeine Anhydrous to promote higher energy levels, prolonging concentration, mental discipline, and self-control. Higher energy levels lead to better physical motivation, which helps users effectively carry out tasks.

In addition to the extensive list of benefits and effects, the supplement has a fast-acting and non-addictive effect paired with neuroprotective properties supported by B vitamins and powerful antioxidants. This combination repairs damaged brain cells and protects them from structural changes while preventing burnouts/crashes.

Pros and Cons


  • Increased energy, focus, motivation
  • Improves memory, learning, and communication
  • Eliminates stress/anxiety, brain fog, and mental blocks
  • Protection against burnouts, cognitive/mental damage, crashes


  • Regular doses are needed for maximum effect
  • It may induce headaches in some users

2. NooCube

NooCube is a well-designed brain-boosting supplement made with natural ingredients. Created by neuroscientists from Wolfson Brands Ltd, a manufacturer well known for its unique wellness aids, NooCube aims to improve complete cognition.

The formula contains a blend of nootropics, vitamins, and minerals that work as both a brain enhancer and nutritional aid.

It improves mental speed, memory, and overall cognition while restoring deficiencies. The formula also contains herbal extracts such as Cats Claw and Oats Straw which promote energy and wakefulness. These components support optimum blood flow to the brain that improves alertness, focus, and concentration.

The NooCube blend has the added benefit of reducing brain fog, anxiety, and mental stress. Eliminating these brain hurdles increases feelings of calm and motivation, which helps users reach their cognitive goals faster.

Pros and Cons


  • Promotes wakefulness, energy, focus, concentration
  • Improves complete cognition and mental processing
  • Lowers stress levels and improves moods/motivation
  • Clean formula with no genetically modified organisms


  • Proprietary blends could lower efficacy in certain aspects
  • Higher possibility of side effects because it lacks clinical doses

3. MindLab Pro

MindLab Pro is a high-potency brain aid specifically designed to improve mental processing and cognition.

Promoted as the world's cleanest nootropic aid, the supplement contains natural nootropic agents such as Citicoline, L- Theanine, N-Acetyl L-Tyrosine, and Rhodiola Rosea.

Combined, these natural nootropics increase both mental and physical energy, directly improving memory, learning, and focus, as well as promoting thinking efficiency. This synergistic blend of ingredients purportedly reduces fatigue and stress while increasing mental capacity, stamina, and physical energy levels.

The formula improves moods, motivation, and physical/mental endurance, making it a popular choice among fitness enthusiasts. MindLab also has neuroprotective properties that prevent mental decline caused by injury, illness, or age. 

Pros and Cons


  • Provides neuroprotective benefits
  • Clean formula free of harmful agents
  • Optimizes all cognitive functions
  • Promotes higher energy, focus, and motivation levels


  • Cycling use is necessary
  • Ingredients are not present in clinically approved doses

4. Modafinil

Modafinil is a prescription medicine for the treatment of sleep disorders such as narcolepsy, shift work sleep disorder, and more.

Although the product was designed to treat specific disorders, it's been used off-label to tackle chronic fatigue, lack of energy, and mood/motivation decline. It also boosts memory and supercharges focus, concentration, and alertness.

This is a beneficial feature for those who need to burn the midnight oil. Modafinil has a single active ingredient, modafinil, that stimulates the central nervous system, encouraging higher energy levels and longer periods of wakefulness. This synthetic smart drug enhances brain function and cognitive performance with limited negative effects.

Pros and Cons


  • FDA-approved, safety guaranteed
  • Has cognitive enhancing properties
  • Treat chronic fatigue and other sleep disorders
  • Supplies the body/mind with a crash-free energy boost


  • It cannot be purchased without a prescription
  • It can be addictive/cause dependence if used incorrectly

5. Alpha Brain

Alpha Brain is a nootropic supplement created by Onnit. The product contains a comprehensive list of natural nootropic ingredients such as Bacopa, Alpha-GPC, Oat straw, and L-Theanine, which work together to support mental speed, concentration, memory, and moods. The formula claims to enhance verbal recall, memory, and executive functioning while enhancing overall brain function.

With the support of ingredients such as L-Tyrosine, the product also boosts energy levels which support feelings of motivation and focus. The potency of this energy-boosting effect has been likened to amphetamines, providing users with safe and rapid results.

Alpha Brain also heightens flow state, which helps users stay in the 'zone' for longer. Its unique blend caters to the brain's nutritional needs as well, restoring declining vitamin and mineral levels.

Pros and Cons


  • Increases energy, focus, motivation 
  • Regulates dopamine and serotonin levels
  • Promotes flexible thinking, working memory
  • 3-in-1 natural formula that supports brain processes


  • It cannot be used during nursing or pregnant 
  • It can only be stacked with products from the Onnit Brand


The nootropic agents cited in this review are definitely the cream of the crop. They can provide several brain-enhancing effects while increasing energy levels and motivation, which are the key components to success.

After taking a closer look at their abilities, benefits, and formulas, we believe they have an excellent safety rate, making them an ideal option for a wide range of users. We also found that these supplements provide users with auxiliary benefits that improve their overall health, making them the best options in our opinion.


Are nootropics safe to use long-term?

Nootropic supplements made using natural ingredients can typically be used long-term without any possibility of tolerance or addiction. However, users are still urged to seek professional advice before using any nootropic for longer than the recommended duration.

Are nootropics accessible and legal?

Nootropics are completely legal, with some agents even carrying FDA approval. Natural nootropic supplements can be purchased script-free from the product's official site or OTC, while regulated nootropics require a prescription from a medical professional.

Do nootropics work immediately after consumption?

It depends on the type of nootropic being consumed. Some nootropics take time to build up in the system before becoming effective. Others start to produce key benefits within 30-60 minutes.

How often should I take a nootropic dose?

Dosage frequency depends on the brand/type of nootropic supplement being used. Thus, each nootropic supplement comes with its own dosage and usage instructions. Users should never take a nootropic dose more than what is recommended.

Can you take several nootropic supplements together?

Yes. Some nootropic supplements can work well with others, building an effective nootropic stack. However, experts encourage users to do their research when stacking to ensure that they are not combining incompatible agents.

About the author 

Laurence Lee

Lee is a neuroscientist who has dedicated his career to understanding the inner workings of the brain. He has seen firsthand the power of these supplements in improving cognitive function and believes that more people should be aware of their benefits. In his articles, Lee shares his extensive knowledge on the subject and provides unbiased reviews of different products.

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